发明名称 |
2-AMIDO-4-ARYLOXY-1-CARBONYLPYRROLIDINE DERIVATIVES AS INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE. |
摘要 |
The present invention relates to compounds of formula (1) that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
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申请公布号 |
MXPA06002476(A) |
申请公布日期 |
2006.06.20 |
申请号 |
MX2006PA02476 |
申请日期 |
2004.09.07 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED. |
发明人 |
JOHN H. VAN DRIE |
分类号 |
A61K31/4178;A61K31/4439;A61K31/497;A61K31/501;A61K31/506;A61K31/517;A61K38/00;A61K38/05;A61K45/06;A61P31/14;C07D401/12;C07D401/14;C07D403/00;C07D403/12;C07D403/14;C07K5/02;C07K5/06;C07K5/10;C07K7/02;(IPC1-7):A61K31/417;A61K31/443 |
主分类号 |
A61K31/4178 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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