MULTI-LAYER DRUG DELIVERY DEVICE AND METHOD OF MANUFACTURINGSAME

摘要

This application relates to a multi-layer drug delivery device and a meth od of manufacture. The device comprises a substrate; at least one first layer o n the substrate containing the drug and a first solvent; and at least one seco nd layer applied to the first layer to regulate release of the drug from the first layer, wherein the second layer comprises a polymer. The first solvent substantially prevents direct contact between the drug and the polymer. When applied to the first layer, the polymer is preferably dissolved in a second solvent which is immiscible with the first solvent to substantially prevent inter-diffusion between the first and second layers. In one application the substrate is a medical device, such as an implantable stent, having a biocompatible outer surface. The second layer is preferably biodegradable, bioabsorbable and/or bioresolvable in vivo to permit gradual exposure of the first layer and elution of the drug therefrom.