| 发明名称 |
Fusion proteins for prodrug activation |
| 摘要 |
The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity to a cytotoxic compound (drug), where the antigen binding region is composed of a single polypeptide chain. It is advantageous for covalently bonded carbohydrates to be present on the polypeptide chain.
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| 申请公布号 |
US7060495(B2) |
申请公布日期 |
2006.06.13 |
| 申请号 |
US19970989896 |
申请日期 |
1997.12.12 |
| 申请人 |
BEHRINWERKE AKTIENEGESELLSCHAFT |
发明人 |
GEHRMANN MATHIAS;SEEMANN GERHARD;BOSSLET KLAUS;CZECH JOERG |
| 分类号 |
A01K67/027;A61K39/395;A61K38/00;A61P35/00;C07K14/00;C07K14/705;C07K16/00;C07K16/18;C07K19/00;C12N1/19;C12N1/21;C12N5/10;C12N9/00;C12N9/24;C12N15/09;C12N15/62;C12N15/81;C12P21/02;C12R1/865;G01N33/53;G01N33/68 |
主分类号 |
A01K67/027 |
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