摘要 |
The present invention provides compounds of formula (I): wherein each R independently represents a halogen atom or a C<SUB>1-4 </SUB>alkyl group; R<SUB>1 </SUB>represents a C<SUB>1-4 </SUB>alkyl group; R<SUB>2 </SUB>represents hydrogen or a C<SUB>1-4 </SUB>alkyl group; R<SUB>3 </SUB>represents hydrogen or C<SUB>1-4 </SUB>alkyl group; R<SUB>4 </SUB>represents a trifluoromethyl group; R<SUB>5 </SUB>represents hydrogen, a C<SUB>1-4 </SUB>alkyl group or C(O)R<SUB>6</SUB>; R<SUB>6 </SUB>represents C<SUB>1-4 </SUB>alkyl, C<SUB>3-7 </SUB>cycloalkyl, NH(C<SUB>1-4 </SUB>alkyl) or N(C<SUB>1-4</SUB>alkyl)<SUB>2</SUB>; m is zero or an integer from 1 to 3; n is an integer from 1 to 3; or a pharmaceutically acceptable salt or solvate thereof; compositions containing the same, processes for their preparation and methods for their use in the treatment of conditions mediated by tachykinins.
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