发明名称 |
WWOX: a tumor suppressor gene mutated in multiple cancers |
摘要 |
The present invention provides the isolation and cloning of WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in several cancers. This gene encodes a tumor suppressor with apoptotic functions. The invention provides WWOX nucleic acid- and polypeptide-based cancer therapies. The invention also provides methods for cancer detection, diagnosis and prognosis involving WWOX nucleic acids and polypeptides.
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申请公布号 |
US7060811(B2) |
申请公布日期 |
2006.06.13 |
申请号 |
US20010978318 |
申请日期 |
2001.10.15 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
ALDAZ C. MARCELO;BEDNAREK ANDRZEJ |
分类号 |
C07H21/02 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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