发明名称 |
Cytotoxic agents comprising taxanes and their therapeutic use |
摘要 |
A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. Novel sulfur-containing taxanes.
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申请公布号 |
US2006122259(A1) |
申请公布日期 |
2006.06.08 |
申请号 |
US20060326504 |
申请日期 |
2006.01.06 |
申请人 |
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发明人 |
CHARI RAVI V.J.;BLATTLER WALTER A. |
分类号 |
A61K31/337;A61K31/452;A61K31/496;A61K31/5377;C07D305/14;C07D413/02 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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