SUBSTITUTED PYRIDONE DERIVATIVE

摘要

Compounds of the formula: (I) [wherein A is the formula: (III-1) R<SUP>3</SUP> is a hydrogen atom, lower alkyl, etc.; m is 0 or 1; R<SUP>1</SUP> is a hydrogen atom, halogen atom, etc.; R<SUP>2</SUP> is a hydroxyl, etc.; p is 0 to 4; X is a carbon atom or nitrogen atom; and each of X<SUP>1</SUP> to X<SUP>4</SUP> is a lower alkyl, etc.], or pharmaceutically acceptable salts thereof. These have a potency antagonistic to binding to histamine H3 receptor, or have a potency inhibiting the constant activity of histamine H3 receptor, and are useful in the therapy of obesity, diabetes, etc.