USE OF ROTTLERIN AND ITS DERIVATIVES AS ACTIVATORS OF BK CHANNEL FOR THERAPY OF HYPERTENSION AND RELATED DISORDERS
摘要
<p>The present invention provides compositions and methods for regulating the BK channel using rottlerin and derivatives thereof. In particular, the present invention provides pharmaceutical compositions for use in treating or preventing BK channel medicated disorders including hypertension and various hyperexcitability disorders. Also provided are compositions and methods for use in post-stroke neuroprotection and in treating or preventing erectile dysfunction. The present invention further provides kits for use in treating or preventing BK channel mediated disorders, comprising the compositions of the present invention.</p>
申请公布号
WO2006060196(A2)
申请公布日期
2006.06.08
申请号
WO2005US41942
申请日期
2005.11.18
申请人
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;MARX, STEVEN, O.;ZAKHAROV, SERGEY, I.