发明名称 |
Stem cell expansion factor blocking gene limiting hox-induced expansion and method using such factor |
摘要 |
The present invention relates to a stem cell expansion factor comprising a blocker which reduces expression level of at least one gene normally limiting HOX-induced expansion of stem cells, whereby reducing expression level of said gene enhances expansion of stem cells containing a HOX peptide. The present invention also relates to a composition for enhancing expansion of stem cells comprising an amino acid sequence having the activity of a HOX peptide, wherein said peptide being able to cross a cell membrane, and a blocker which reduces expression level of at least one gene normally limiting HOX-induced expansion of stem cells, whereby reducing expression level of said gene in the presence of a HOX peptide enhances expansion of stem cells. The preferred HOX peptide is HOXB4 and the preferred gene is PBX.
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申请公布号 |
US2006121566(A1) |
申请公布日期 |
2006.06.08 |
申请号 |
US20030530413 |
申请日期 |
2003.10.06 |
申请人 |
INSTITUTE DE RECHERCHES CLINIQUES DE MONTREAL |
发明人 |
SAUVAGEAU GUY;HUMPHRIES KEITH;KROSL JANA |
分类号 |
C07H21/04;A61K35/12;A61K38/17;C07K14/47;C07K14/475;C12N5/0789;C12N15/11;C12P21/06 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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