<p>Use of a compound of formula (I) where R<SUP>1</SUP> is a C<SUB>4-6 </SUB>alkylene linkage optionally substituted by a C<SUB>1-4</SUB>alkyl group; R<SUP>2</SUP> is =NH, -NH<SUB>2</SUB> or -OH; R<SUP>3</SUP> is C<SUB>1-5</SUB> alkyl optionally terminated by a hydroxy, phenyl or a 5- or 6- membered heterocyclic group such as furyl or N-imidazolyl and R<SUP>4</SUP> is H; or R<SUP>3</SUP> and R<SUP>4</SUP> together form a C<SUB>3-5</SUB> alkylene linkage; to produce a topical refreshing or cooling sensation in a mammal such as a human.</p>
申请公布号
WO2006058600(A1)
申请公布日期
2006.06.08
申请号
WO2005EP11972
申请日期
2005.11.07
申请人
UNILEVER PLC;UNILEVER NV;FOSTER, ALISON, JAYNE;VAN DER LOGT, CORNELIS, PAUL, ERIK;LOURBAKOS, AFRODITE;TAREILUS, ERWIN, WERNER
发明人
FOSTER, ALISON, JAYNE;VAN DER LOGT, CORNELIS, PAUL, ERIK;LOURBAKOS, AFRODITE;TAREILUS, ERWIN, WERNER