发明名称 |
Pyridine derivatives useful as CD40:CD154 binding interruptor compounds and use thereof to treat immunological complications |
摘要 |
The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction. |
申请公布号 |
AU2001287041(B2) |
申请公布日期 |
2006.06.08 |
申请号 |
AU20010287041 |
申请日期 |
2001.08.31 |
申请人 |
BIOGEN IDEC MA INC. |
发明人 |
MARY-BETH CARTER;HUW M NASH;ZHONGLI ZHENG;HUW M. NASH;GEORGE R. LENZ;LIHONG SUN;GEORGE R LENZ;LEONID KIRKOVSKY;GERALD W SHIPPS JR;MARY-BETH CARTER;SATISH JINDAL;YU-SHENG LIAO;SATISH JINDAL;ZHONGLI ZHENG;LIHONG SUN;YEN-MING HSU;SUSAN MROSE;LEONID KIRKOVSKY;YEN-MING HSU;DAVID THOMAS;YUSHENG LIAO;GERALD W. SHIPPS JR.;SUSAN MROSE;DAVID THOMAS |
分类号 |
C12N15/00;F25B9/00;A61K31/444;A61P1/04;A61P1/16;A61P9/02;A61P9/04;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P17/06;A61P19/02;A61P25/28;A61P27/02;A61P29/00;A61P35/02;A61P37/00;A61P37/06;A61P37/08;C07C311/47;C07D401/14;F25B9/14 |
主分类号 |
C12N15/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|