METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS
摘要
<p>Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient.</p>
申请公布号
WO2006060697(A1)
申请公布日期
2006.06.08
申请号
WO2005US43706
申请日期
2005.12.05
申请人
ADHEREX TECHNOLOGIES, INC.;SPECTOR, TOM;PETERS, WILLIAM, PAUL;KUFE, DONALD, WILLIAM;HUBER, BRIAN
发明人
SPECTOR, TOM;PETERS, WILLIAM, PAUL;KUFE, DONALD, WILLIAM;HUBER, BRIAN