发明名称 |
INTERFERON-BETA COMPOSITE |
摘要 |
The present invention relates to a complex between interferon-² and polyethylene glycol, which has high biological activity, and to a method for producing the complex at high efficiency. Namely, the present invention relates to a method for producing an interferon-² complex comprising binding interferon-² to polyethylene glycol in the presence of at least one additive selected from the group consisting of oligosaccharides having 5 or less sugar units, monosaccharides, their corresponding sugar alcohols, and C 2-6 polyhydric alcohols, and to an interferon-² complex produced by the method, which has polyethylene glycol specifically bound with lysine located at the 19th or 134th position in the amino acid sequence of interferon-².
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申请公布号 |
EP1666496(A1) |
申请公布日期 |
2006.06.07 |
申请号 |
EP20040772408 |
申请日期 |
2004.08.24 |
申请人 |
TORAY INDUSTRIES, INC. |
发明人 |
NARUMI, HIDEKI;TSUSHIMA, YOSHIAKI;YAMASHITA, KOJI;SONE, SABUROU;SATO, MIYUKI;TANIGUCHI, TADATSUGU |
分类号 |
A61K38/21;A61K47/48;C07K14/565;(IPC1-7):C07K14/565 |
主分类号 |
A61K38/21 |
代理机构 |
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地址 |
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