发明名称 |
BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS |
摘要 |
Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>7</SUP>, R<SUP>8</SUP>, R<SUP>9 </SUP>and R<SUP>10 </SUP>are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds. |
申请公布号 |
EP1663210(A1) |
申请公布日期 |
2006.06.07 |
申请号 |
EP20040781809 |
申请日期 |
2004.08.20 |
申请人 |
ARRAY BIOPHARMA, INC. |
发明人 |
WALLACE, ELI, M.;LYSSIKATOS, JOSEPH, P.;MARLOW, ALLISON, L.;HURLEY, BRIAN, T.;KOCH, KEVIN |
分类号 |
C07D235/06;C07D401/06;C07D401/12;C07D401/14;C07D403/04;C07D403/06;C07D403/12;C07D405/06;C07D413/04;C07D413/06;C07D417/06;C07D417/12;C07F9/6506;C07F9/6558 |
主分类号 |
C07D235/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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