Composition comprising a tachykinin receptor antagonist and a selective serotonin reuptake inhibitor

摘要

A composition comprising a compound of formula (I)
wherein
R represents halogen or C 1-4 alkyl ;
R 1 represents C 1-4 alkyl;
R 2 or R 3 independently represent hydrogen or C 1-4 alkyl;
R 4 represents trifluoromethyl, C 1-4 alkyl, C 1-4 alkoxy, trifluoromethoxy or halogen;
R 5 represents hydrogen , C 1-4 alkyl or C 3-7 cycloalkyl;
R 6 is hydrogen and R 7 is a radical of formula (W):
or R 6 is a radical of formula (W) and R 7 is hydrogen;
X represents CH 2 , NR 5 or O;
Y represents Nitrogen and Z is CH or Y represents CH and Z is Nitrogen;
A represents C(O) or S(O)q, provided that when Y is nitrogen and Z is CH, A is not S(O)q;
m is zero or an integer from 1 to 3;
n is an integer from 1 to 3;
p and q are independently an integer from 1 to 2;
or pharmaceutically acceptable salts and solvates thereof and a selective serotonin reuptake inhibitor.