| 发明名称 |
Selective acylation of epsilon-amino groups in insulin |
| 摘要 |
The present invention relates to the acylation of proteins. More particularly, the invention relates to a one-step process for selectively acylating the free epsilon -amino group of insulin, insulin analog, or proinsulin in the presence of a free alpha -amino group. |
| 申请公布号 |
EP0712862(B1) |
申请公布日期 |
2006.06.07 |
| 申请号 |
EP19950308167 |
申请日期 |
1995.11.14 |
| 申请人 |
ELI LILLY AND COMPANY |
发明人 |
BAKER, JEFFREY CLAYTON;CHEN, VICTOR JOHN;KRIAUCIUNAS, AIDAS VLADAS;MOSER, BRIAN ALLEN;HANQUIER, JOSE MICHAEL;SHUMAN, ROBERT THEODORE |
| 分类号 |
A61K38/28;C07K14/62;C07K1/107;C07K1/113;C07K1/13 |
主分类号 |
A61K38/28 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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