发明名称 |
Cyclic lipopeptide acylase |
摘要 |
The present invention provides a cyclic lipopeptide acylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase.
[wherein R 1 is acyl; R 2 is hydroxy or acyloxy; R 3 is hydrogen or hydroxy; R 4 is hydrogen or hydroxy; R 5 is hydrogen or hydroxysulfonyloxy; and R 6 is hydrogen or carbamoyl] |
申请公布号 |
EP1666587(A1) |
申请公布日期 |
2006.06.07 |
申请号 |
EP20060110934 |
申请日期 |
1997.06.11 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
UEDA, SATOSHI;TANAKA, MIHO;EZAKI, MASAMI;SAKAMOTO, KAZUTOSHI;HASHIMOTO, SEIJI;OOHATA, NOBUTAKA;TSUBOI, MASARU;YAMASHITA, MICHIO |
分类号 |
C12N9/80;A61K38/00;C07K5/12;C07K7/56;C12N1/14;C12N9/14;C12P21/02 |
主分类号 |
C12N9/80 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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