Method of establishing the optimal radiation dose for a radiopharmaceutical treatment of disease

摘要

A method for determining the number of millicurie to be administered to a patient so as to deliver a given centigray (cGy) dose of either the patient's lean body of the patient's total body. The method includes the steps of injecting a radioactive tracer into a patient, determining radiation levels in the whole body, calculating a geometric mean based on the radiation levels, determining the percent-injected activity remaining in the body at each time point, plotting the percent-injected activity versus calculated time from infusion on a log-linear graph, determining the effective half-life and the rate of clearance from the log-linear graph, cross-indexing the effective half-life vlue with the patient's body weight, and multiplying the determined amount of therapeutic millicurie per centigray by the amount of desired centigray to be administered.