Tumor-inhibiting platinum (II) oxalate complexes

摘要

A tumor-inhibiting platinum (II) oxalate complex and its use as a therapeutic agent are provided, in particular as a tumor-inhibiting medicament. The complex may be compounds of the general formula (I), wherein the substituents R¹, R^1', R², R^2', R³, R^3', R⁴, and R^4' are independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted cycloalkenyl, unsubstituted or substituted aryl and unsubstituted or substituted alkylaryl radicals, the substituents R⁵, R^5', R⁶, and R^6' are independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, and unsubstituted or substituted alkenyl radicals, and wherein optionally in each case at least two of the substituents R¹, R^1', R², R^2', R³, R^3', R⁴, and R^4' can form with one another at least one unsubstituted or substituted alkylene, unsubstituted or substituted alkenylene radical or an unsubstituted or substituted aromatic ring, and wherein optionally at least one of the carbon atoms of the cyclohexane ring bearing the substituents R¹, R^1', R², R^2', R³, R^3', R⁴, and R^4' is replaced by a heteroatom, and if the heteroatom is oxygen, the substituents R¹, R^1', R², R^2', R³, R^3', R⁴, and R^4' can additionally be hydroxy radicals, and pharmaceutically compatible salts of them, provided that at least one of the substituents R¹, R^1', R², R^2', R³, R^3', R⁴, or R^4' is not equal to hydrogen and the substituents R¹ or R^1' and R⁴ or R^4' do not form any unsubstituted C_1-2-alkylene radical with one another.