Drug efflux pump inhibitor

摘要

A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I): wherein, R¹ and R² represent hydrogen atom, a halogen atom, hydroxyl group or the like, W¹ represents -CH-CH-, -CH₂O-, -CH₂CH₂- or the like; R³ represents hydrogen atom, a halogen atom, hydroxyl group or an amino group; R⁴ represents hydrogen atom, a group of -OZ_0-4R⁵ (Z_0-4 represents an alkylene group, a fluorine-substituted alkylene group or a single bond, and R⁵ represents a cyclic alkyl group, an aryl group or the like); W² represents a single bond or -C(R⁸)-C(R⁹)- (R⁸ and R⁹ represent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but W² and Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.