| 摘要 |
Use of a sulfamide derivative (I) or its salts, solvates or isomers, for the nontherapeutic care of skin. Use of a sulfamide derivative (I) of formula (R 3>)(R 4>)N-S(=O)(=O)(N)(R 1>)(R 2>) or its salts, solvates or isomers, for the nontherapeutic care of skin. Either R 1>-R 4>H or 1-10C (preferably 1-4C) alkyl (optionally substituted by 1-5 groups of OR 5>, NR 6>R 7>or SiR 8>R 9>R 10>; and 1-3C replaced by heteroatoms (N, S, O, Si or sulfonyl (SO 2) e.g. O-SO 2-NR 6>R 7>)); or NR 1>R 2>, NR 3>R 4>5-7 membered heterocycle (optionally substituted by 1-4 OH and/or NR 6>R 7>) (where the heterocycle is pyrrolidine, piperazine, morpholine, azepane, pyrazolidine, imidazolidine, oxazolidine or partially unsaturated derivatives of pyrrole, pyridine or pyrimidine); or N-(SO 2)-N + ((R 1>+R 3>) or (R 2>+R 4>)) : 5-9 membered heterocycle (optionally substituted by 1-4 OH and/or NR 6>R 7>(1,2,5-thiadiazolidine 1,1-dioxide, 1,2,6-thiadiazinane 1,1-dioxide, 1,2,7-thiadiazepane 1,1-dioxide, 1,2,8-thiadiazocane 1,1-dioxide or 1,2,9-thiadiazonane 1,1-dioxide)); R 6>, R 7>H or 1-6C alkyl; R 5>R 6>, OR 5>, PO 4or SO 4; and R 8>-R 10>1-6C alkyl. Independent claims are also included for: (1) a sulfamide derivative (II) of formula R 11>-NH-S(=O) 2-NH-CH(R 12>)(SiR 10>R 9>R 8>) and its salts, solvates or isomers; (2) a sulfamide derivative (III) of formula (NH 2-S(=O) 2-N(Ra 13>)-CH 2-R 13>) and its salts, solvates or isomers; (3) a sulfamide derivative (IV) of formula (Y-CH(OX)-CH 2-N(R 3>)-S(=O) 2-N(R 1>)-CH 2-CH(OXa)(Ya)); (4) a cosmetic composition (A), comprising (I), (II), (III) or (IV) with the exception of N,N'-bis(2-hydroxyethyl)sulfamide; and (5) a process of cosmetic treatment for nontherapeutic care and/or skin make-up, comprises applying (A), comprising (I), (II), (III) and/or (IV) to the skin. R 12>H, SiR 8>R 9>R 10>or 1-9C alkyl (optionally substituted by 1-5 groups of OR 5>, NR 6>R 7>or SiR 8>R 9>R 10>; and optionally 1-3C replaced by heteroatom of N, S, O, Si or a sulfonyl group (SO 2)); R 11>1-6C alkyl (optionally substituted by 1-5 groups of OR 5>or SiR 8>R 9>R 10>or OSO 2-NRRa); R 13>1-9C alkyl (substituted by 1-5 groups of OR 5>, NR 6>R 7>or O-SO 2NRRa); Ra 13>H or 1-4C alkyl; either X, Xa : R 5>; and Y, Ya : H or CH 2Z; or X+Xa : H; and Y+Ya : covalent bond; or -CH(Ya)(OXa), -CH(Y)(OX) : dimethyldioxolane; and Z : NH 3, NR 6>R 7>or OR 5>. Provided that, X, Xa, Y and Ya do not represent simultaneously a hydrogen atom. |
