ACYCLIC SULPHONAMIDES

摘要

Compounds of formula: (I) are found to antagonise N-type calcium channels wherein: - A is a 5- to 10-membered heteroaryl or heterocyclyl moiety, said moiety being optionally fused to a phenyl, 5- to 6-membered heteroaryl, C₃-C₆ carbocyclyl or 5- to 6- ­membered heterocyclyl group; - B is a bond or a C₁-C₆ alkyl or C₂-C₆ alkenyl moiety; - either (a) R¹ is hydrogen or C₁-C₆ alkyl and R² is hydrogen, C₁-C₆ alkyl, C₂-C₆ alkenyl, halogen, hydroxy, thio, amino, -Het-L or -L-Het-L', wherein L and L' are the same or different and represent C₁-C₆ alkyl or C₂-C₆alkenyl and Het is O, S or NR, wherein R is hydrogen or C₁-C₆ alkyl or (b) R¹ and R² form, together with the carbon to which they are attached, a 5- to 10-membered heterocyclyl or a C₃-C₈ carbocyclyl moiety; R³ is hydrogen, C₁-C₆ alkyl, C₂-C₆ alkenyl or -L-Het-L', wherein L, L' and Het are as defined above; and - R⁴, R⁵ and R⁶ are the same or different and represent hydrogen, halogen, hydroxy, amino, thio, C₁-C₆ alkyl, C₂-C₆ alkenyl, C₁-C₆ alkoxy, C₁-C₆ alkylthio, mono(C₁-C₆ alkyl)amino or di(C₁-C₆ alkyl)amino.