| 摘要 |
<p>A method of delivering a nasal spray. A sprayer having a formulation comprising olopatadine is provided. A spray of the formulation is delivered to a subject's nose. The spray may have a spray characteristic comprising a spray pattern having a longest axis of 20-45 mm, a shortest axis of 14-20 mm, and an ellipticity of 1-1.8. The spray may also have a spray characteristic comprising a droplet size distribution having a D10 of 15-30μm, a D50 of 30-60μm, a D90 of 50-150μm, a SPAN of not more than 3, and a % Volume of <10μm of less than 4%.</p> |
