| 摘要 |
The invention provides a simple colorimetric assay method for screening for propensity for, or occurrence of, neurodegeneration in the brain. The assay relies on measuring enzymatic activity of a soluble monomeric form of acetylcholinesterase (G<SUB>1</SUB>-AChE) added to biological samples such as serum or plasma samples. Exogenous G<SUB>1</SUB>-AChE with such samples from patients with, for example, Motor Neurone Disease associated with amyotrophic lateral sclerosis, Parkinson's disease or Alzheimer's disease has selectively been found to exhibit significantly higher activity than in similarly treated control samples. |
