发明名称 |
Method for obtaining antigenic aggregates and the use thereof in formulations |
摘要 |
<p>The present invention is related to the method for obtaining aggregated antigenic structures that are able to enhance the immune response to antigens, administered by systemic and/or mucosal routes, to generate potent immune responses, as well as chemical structures resulting from the application of this method, the formulations obtained from such structures and their use. <??>The method describes the preparation of new aggregated antigenic structures by using aggregating, delipidating or oxidizing compounds allowing the release of lipids from the particle and its aggregation in a heterogeneous fashion, selecting afterwards particle aggregates with sizes between 30 and 500 nm by a molecular exclusion process. The aggregation state may also be induced inside the yeast by varying the incubation conditions. The resulting structures may be conveniently used adjuvanted or in a formulation together with several antigens, to produce a synergistic effect of these components regarding the immunogenicity of the response obtained. The preparation may also contain stabilizing and preserving substances. <??>The resulting antigenic structures may be applied in the pharmaceutical industry as preventive or therapeutic vaccine formulations for human or veterinary use and as a part of diagnostic systems.</p> |
申请公布号 |
AU2002221518(B2) |
申请公布日期 |
2006.06.01 |
申请号 |
AU20020221518 |
申请日期 |
2001.11.29 |
申请人 |
CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA |
发明人 |
DINA TLEUGABULOVA;GERARDO ENRIQUE GUILLEN NIETO;JULIO CESAR AGUILAR RUBIDO;VIVIANA FALCON CAMA;LUIS JAVIER CRUZ RICONDO;EDUARDO PENTON ARIAS;MINERVA SEWER MENSIES;YANET TAMBARA HERNANDEZ;ILOKI ASSANGA SIMON BERNARD;VERENA LUCILA MUZIO GONZALEZ |
分类号 |
A61K9/10;A61K39/29;A61K39/00;A61K39/02;A61K39/095;A61K39/12;A61K39/39;A61K47/40;A61P31/00;A61P31/12;A61P31/14;A61P31/18;A61P31/20;A61P35/00;A61P37/00;A61P37/04;C07K14/02;C07K14/025;C07K14/16;C07K14/18;C07K14/22 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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