Halothenoyl-cyclopropane-1-carboxylic acid derivatives

摘要

Compounds of formula (I) wherein R is hydroxy, linear or branched C₁-C₆ alkoxy, phenoxy, benzyloxy, a group -N(R¹R²) wherein R¹ is hydrogen, linear or branched C₁-C₄ alkyl, benzyl, phenyl and R² is hydrogen or linear or branched C₁-C₄ alkyl, or R is a glycoside residue or a primary alkoxy residue from ascorbic acid, optionally having one or more hydroxy groups alkylated or acylated by linear or branched C₁-C₄ alkyl or acyl groups; X is a halogen atom and n 1 or 2 are long lasting inhibitors of kynurenine 3-monooxygenase (KMO) and potent glutamate (GLU) release inhibitors.