发明名称 |
Span-xb gene and protein for the diagnosis and treatment of cancer |
摘要 |
The present invention relates to methods for diagnosing cancer in a subject The method involves obtaining a biological sample from a subject and measuring SPAN-Xb expression level in the biological sample. The SPAN-Xb expression level in the biological sample is compared to the SPAN-Xb expression level in a control sample from a subject devoid of cancer, where a greater SPAN-Xb expression level in the biological sample compared to the SPAN-Xb expression level in the control sample is indicative of the subject having cancer. Methods for monitoring progression/regression of cancer in a subject are also disclosed. The present invention also relates to methods of treating a subject with cancer. The method involves administering to the subject a therapeutically effective amount of an agent capable of eliciting an immunological response against SPAN-Xb protein or specifically recognizing a SPAN-Xb protein, under conditions effective to-treat a cancer characterized by cells expressing SPAN-Xb.
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申请公布号 |
US2006115817(A1) |
申请公布日期 |
2006.06.01 |
申请号 |
US20050525623 |
申请日期 |
2005.11.14 |
申请人 |
LIM SEAH H;WANG ZHIQING;ZHANG YANA |
发明人 |
LIM SEAH H.;WANG ZHIQING;ZHANG YANA |
分类号 |
C12Q1/68;C07K14/47;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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