Nobel compounds having selective inhibiting effect at gsk3

摘要

The present invention relates to new compounds of formula (I) wherein: Z is N and X is CH or N; Y is CONR⁵; P is phenyl or a 5 or 6 membered heteroaromatic ring containing one or more heteroatoms selected from N, O or S; Q is phenyl or a 5 or 6 membered aromatic heterocyclicc ring containing one or more nitrogen atoms; R is C_1-6alkylNR¹⁰R¹¹ or C_1-6alkylazetidine; R¹⁰ is hydrogen, C_1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, C_0-6alkylC_3-6cycloalkyl, C_0-6alkylaryl, C_0-61alkylheteroaryl or C_1-6alkylNR⁸R⁹; R¹¹ is C_1-6alkylNR⁸R⁹, C_0-6alkylC_3-6cycloalkyl or C_0-6alkylheterocycloalkyl; as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.