Taxol enhancer compounds

摘要

One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C=Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or -C(R₇R₈)-. R₁ is an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group, or a substituted non-aromatic heterocyclic group, R₂-R₄ are independently -H, an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group, a substituted non-aromatic heterocyclic group, an aryl group or a substituted aryl group, or R₁ and R₃ taken together with the carbon and nitrogen atoms to which they are bonded, and/or R₂ and R₄ taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. R₅-R₆ are independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R₇ and R₈ are each independently -H, an aliphatic or substituted aliphatic group, or R₇ is -H and R₈ is a substituted or unsubstituted aryl group, or, R₇ and R₈, taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is -O or -S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent.