发明名称 |
SOLID FORMULATIONS OF LIQUID BIOLOGICALLY ACTIVE AGENTS |
摘要 |
The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product ; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent. |
申请公布号 |
WO2006056064(A1) |
申请公布日期 |
2006.06.01 |
申请号 |
WO2005CA01790 |
申请日期 |
2005.11.28 |
申请人 |
LABOPHARM INC.;LABOPHARM EUROPE LIMITED;LABOPHARM (BARBADOS) LIMITED |
发明人 |
RAVENELLE, FRANCOIS;GORI, SANDRA;LESSARD, DAVID;LUO, LAIBIN;LE GARREC, DOROTHEE;SMITH, DAMON |
分类号 |
A61K31/47;A61K9/10;A61K9/14;A61K31/05;A61K31/08;A61K47/30 |
主分类号 |
A61K31/47 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|