Bis(acridinecarboxamide) or bis(phenazinecarboxamide) derivative, preparation, use its and pharmaceutical compositions

摘要

Bis(acridinecarboxamide) or bis(phenazinecarboxamide) derivatives of formula I wherein each X, which may be the same or different in a given molecule, is -CH= or -N=, each of R1 to R4 which may be the same or different, is H, C1-C4 alkyl, OH, SH, NH2, C1-C4 alkoxy, aryl, aryloxy, NHR, N(R)2, SR or SO2R wherein R is C1-C4 alkyl, CF3, NO2 or halogen, or R1 and R2 together form a methylenedioxy group, each of R5 and R6, which may be the same or different, is H or C1-C4 alkyl, Z is (CH2)n,(CH2)nO(CH2)n, (CH2)nN(R7)(CH2)n, (CH2)nN(R7)(CH2)mN(R7)(CH2)n or (CH2)nN(CH2CH2)2N(CH2)n wherein R7 is H or C1-C4 alkyl and n and m, which may be the same or different, are each an integer of 1 to 4; pharmaceutically acceptable acid addition salts or N-oxides thereof; a process for their preparation; intermediates for their preparation; a pharmaceutical composition containing thereof and use its.