INDUCTION OF ANTIVIRAL NEUTRALIZING ANTIBODIES IN HUMANS AND ANIMALS
摘要
<p>The invention relates to immunogenic constructs that in principle comprise two different domains of the transmembrane envelope protein of enveloped viruses including retroviruses including HIV, a pharmaceutical agent for inducing humoral neutralizing immune responses to viral infections and to a kit for the detection of antibodies and viral antigens. The invention also relates to a method for inducing an antibody response and to a method for the passive immunization of an organism using neutralizing antibodies that were obtained using the above-mentioned immunogenic constructs. Finally, the invention relates to a bioassay for detecting viral infection and for detecting the production of neutralizing antibodies.</p>
申请公布号
EP1660523(A2)
申请公布日期
2006.05.31
申请号
EP20040786181
申请日期
2004.08.26
申请人
BRD, VERTRETEN DURCH DAS BM FUER GESUNDHEIT UND SOZIALE SICHERUNG, LETZTVERTRETEN DURCH DEN PRAESIDENTEN DES ROBERT-KOCH-INST.
发明人
FIEBIG, UWE;SCHMOLKE, MIRCO;DENNER, JOACHIM;KURTH, REINHARDT;KARLAS, ALEXANDER