Tetrahydropyrimidine-2-one derivatives and their uses

摘要

Use of a compound according to Formula [I]: or a salt thereof to produce a cooling sensation, wherein R¹ and R² are independently selected from hydrogen or halogen atoms; hydroxy, cyano, nitro, mercapto, carbonyl, sulfone and carboxy groups; or optionally substituted alkyl, alkenyl, alkoxy, alkylthio, aryl, aryloxy, arylthio, amino, siloxy, ester and heterocyclic groups, with the proviso that when R¹ is 2-hydroxyphenyl, R² is other than 3-nitrophenyl.