发明名称 |
METHODS OF MAKING OPTICALLY PURE (R)- AND (S)- DIDESMETHYLSIBUTRAMINE |
摘要 |
Methods of making and using racemic and optically pure metabolites of sibutramine, and pharmaceutically acceptable salts, solvates, and clathrates thereof, are disclosed. Pharmaceutical compositions and dosage forms are also disclosed which comprise a dopamine reuptake inhibitor, such as a racemic or optically pure sibutramine metabolite, and optionally an additional pharmacologically active compound. |
申请公布号 |
EP1246789(B1) |
申请公布日期 |
2006.05.31 |
申请号 |
EP20010901941 |
申请日期 |
2001.01.10 |
申请人 |
SEPRACOR INC. |
发明人 |
SENANAYAKE, CHRISANTHA, H.;FANG, QUN, K.;HAN, ZHENGXU;KRISHNAMURTHY, DHILEEPKUMAR |
分类号 |
A61K35/48;C07C209/88;A61K31/00;A61K31/11;A61K31/135;A61K31/137;A61K45/06;A61P3/04;A61P15/10;A61P25/00;A61P25/02;A61P25/04;A61P25/06;A61P25/30;C07B57/00;C07C45/44;C07C47/395;C07C47/457;C07C209/60;C07C211/29;C07C249/02;C07C251/18 |
主分类号 |
A61K35/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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