发明名称 |
TREFOIL FACTOR 3 (TFF3) AS A TARGET FOR ANTI-CANCER THERAPY |
摘要 |
<p>The present invention is directed to methods of treating and preventing cancer, such as cancer characterized by differential expression of trefoil factor 3 (TFF3). The methods include administering to a patient an agent that modulates TFF3 activity or expression. The present invention is further directed to reducing the physiological effects of TFF3 expression in cells, including inhibiting cell motility and resistance to apoptosis. Oligonucleotides and antibodies that can modulate expression or activity of TFF3 are also provided.</p> |
申请公布号 |
EP1660136(A2) |
申请公布日期 |
2006.05.31 |
申请号 |
EP20040780358 |
申请日期 |
2004.08.05 |
申请人 |
CHIRON CORPORATION |
发明人 |
JANATPOUR, MARY J.;GARCIA, PABLO;REINHARD, CHRISTOPH |
分类号 |
A61B;A61K39/395;A61K48/00;C07K14/575;C07K16/26;C12N15/113;(IPC1-7):A61K48/00 |
主分类号 |
A61B |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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