| 摘要 |
THE INVENTION PROVIDES A PROCESS FOR THE PREPARATION OF A COMPOUND OF THE FORMULA: OR AN ACID ADDITION OR BASE SALT THEREOF, WHEREIN R IS PHENYL OPTIONALLY SUBSTITUTED BY 1 TO 3 SUBSTITUENTS EACH INDEPENDENTLY SELECTED FROM HALO AND TRIFLUOROMETHYL; R1 IS C1-C6 ALKYL; AND "HET" IS PYRIMIDINYL OPTIONALLY SUBSTITUTED BY 1 TO 3 SUBSTITUENTS EACH INDEPENDENTLY SELECTED FROM C1-C4 ALKYL, C1-C4 ALKOXY, HALO, OXO, BENZYL AND BENZYLOXY, COMPRISING REACTION OF A COMPOUND OF THE FORMULA: WHEREIN R IS AS PREVIOUSLY DEFINED FOR A COMPOUND OF THE FORMULA (I), WITH A COMPOUND OF THE FORMULA: WHEREIN R1 AND "HET" ARE AS PREVIOUSLY DEFINED FOR A COMPOUND OF THE FORMULA (I) AND X IS CHLORO, BROMO OR IODO, IN THE PRESENCE OF ZINC, IODINE AND/OR A LEWIS ACID AND AN APROTIC ORGANIC SOLVENT: SAID PROCESS BEING OPTIONALLY FOLLOWED BY CONVERSION OF THE COMPOUND OF THE FORMULA (I) TO AN ACID ADDITION OR BASE SALT THEREOF.
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