发明名称 |
Polymorph of ä6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-ylü-(3e) |
摘要 |
The invention is concerned with a novel polymorph of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. This polymorph exhibits superior properties compared to the previously known forms of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. The [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride is an inhibitor of tyrosine kinase enzymes, and are useful in the treatment of cancer. Also disclosed are methods of making and using the novel polymorph, as well as pharmaceutical compositions containing the novel polymorph. |
申请公布号 |
ZA200506339(B) |
申请公布日期 |
2006.05.31 |
申请号 |
ZA20050006339 |
申请日期 |
2005.08.08 |
申请人 |
F.HOFFMAN-LA ROCHE AG |
发明人 |
BUBENDORF, ANDRE, G.;MICHAEL HENNIG;PIRMIN HIDBER;GOESTA RIMMLER;FRANZISKA ROHRER |
分类号 |
A61K;A61K31/517;A61P;A61P35/00;C07D;C07D239/94 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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