| 发明名称 |
Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B |
| 摘要 |
The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification. |
| 申请公布号 |
ZA200501680(B) |
申请公布日期 |
2006.05.31 |
| 申请号 |
ZA20050001680 |
申请日期 |
2005.02.25 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
DANIEL BENIGNI;SHU-JEN CHIANG;BRUCE EAGAN;DAVID HOU;TULLY, THOMAS, P.;IVAN HARGRO;GABRIEL GALVIN;CONLOGUE, CARY, W.;ROBERT STANKAVAGE;HSING HOU;DENNIS GU;LES MINZMYER;DAVIS, BRIAN, L.;MARK MASCARI;GREGORY STEIN;COMEZOGLU, FAHRI, T. |
| 分类号 |
C12P17/02;A61K;C07D;C07D417/02;C07D417/06;C07D493/00;C07D493/04;C12N1/20;C12N5/06;C12N9/52;C12P17/14;C12P17/16;C12P17/18 |
主分类号 |
C12P17/02 |
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