发明名称 |
HIGHLY SELECTIVE NOREPINEPHRINE REUPTAKE INHIBITORS AND METHODS OF USING THE SAME |
摘要 |
Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a compound having a pharmacological selectivity of serotonin (Ki)/norepinephrine (Ki) of at least about 5000. Examples of such compounds include reboxetine, and more preferably optically pure (S,S) enantiomer of reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.
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申请公布号 |
CA2375908(C) |
申请公布日期 |
2006.05.30 |
申请号 |
CA20002375908 |
申请日期 |
2000.06.22 |
申请人 |
PHARMACIA & UPJOHN COMPANY |
发明人 |
WONG, ERIK H. F.;CETERA, PASQUALE;BIRGERSON, LARS;TAYLOR, DUNCAN P.;AHMED, SAEEDUDDIN;MARSHALL, ROBERT CLYDE;MCARTHUR, ROBERT |
分类号 |
A61K31/5375;A61K45/00;A61K31/00;A61P1/14;A61P3/04;A61P11/00;A61P13/10;A61P25/00;A61P25/02;A61P25/06;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/32;A61P25/34;A61P25/36;A61P39/02;A61P43/00 |
主分类号 |
A61K31/5375 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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