Caspase inhibitors and uses thereof

摘要

This invention provides caspase inhibitors having the formula: wherein Ring A is an optionally substituted piperidine, tetrahydroquinoline or tetrahydroisoquinoline ring; R¹ is hydrogen, CHN₂, R, or -CH₂Y; R is an optionally substituted group selected from an aliphatic group, an aryl group, an aralkyl group, a heterocyclic group, or an heterocyclylalkyl group; Y is an electronegative leaving group; R² is CO₂H, CH₂CO₂H, or esters, amides or isosteres thereof; Ar is an optionally substituted aryl group; and R³ is hydrogen, an optionally substituted C_1-6 alkyl, F₂, CN, aryl or R³ is attached to Ar to form an unsaturated or partially saturated five or six membered fused ring having 0-2 heteroatoms. The compounds are useful for treating caspase-mediated diseases in mammals.