发明名称 |
Bi-specific antibodies for pre-targeting diagnosis and therapy |
摘要 |
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable conjugate. The targetable conjugate comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable conjugate further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.
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申请公布号 |
US7052872(B1) |
申请公布日期 |
2006.05.30 |
申请号 |
US19990382186 |
申请日期 |
1999.08.23 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
HANSEN HANS J.;GRIFFITHS GARY L.;LEUNG SHUI-ON;MCBRIDE WILLIAM J.;QU ZHENGXING |
分类号 |
A61K39/395;C07K16/00;C12P21/04 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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