发明名称 |
Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression |
摘要 |
The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells by inhibiting the leading strand viral DNA synthesis. More particularly, the present invention demonstrates that D-BP is phosphorylated by EGF-R protein tyrosine kinase. Methods of increasing transcription and promoting replication of transgenes exploiting this information are disclosed herein.
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申请公布号 |
US7052692(B1) |
申请公布日期 |
2006.05.30 |
申请号 |
US19980145379 |
申请日期 |
1998.09.01 |
申请人 |
ADVANCED RESEARCH & TECHNOLOGY INSTITUTE |
发明人 |
SRIVASTAVA ARUN;QING KEYUN;WANG XU-SHAN;PONNAZHAGAN SELVARANGAN;BAJPAI ANIL |
分类号 |
A61K48/00;A61K39/395;C07H21/04;C12N15/63;C12N15/864 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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