发明名称 |
Histoplasma capsulatum catalase sequences and their use in the detection of Histoplamsa capsulatum and histoplasmosis |
摘要 |
The present invention describes Histoplasmosis capsulatum catalase A and catalase P nucleic acid and protein sequences as reagents for the detection of H. capsulatum infection. Specifically, the invention describes intron sequences from the H. capsulatum catalase A (CATA) and catalase P (CATP) genes which can be used for hybridization and PCR based detection of H. capsulatum infection. In another embodiment, assays for H. capsulatum catalase P or catalase A polypeptides are used as diagnostic tests for H. capsulatum infection and histoplasmosis, respectively. Also described is the differentiation of H. capsulatum from Blastomyces dermititidis based on a H. capsulatum catalase P PCR based assay.
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申请公布号 |
US7052837(B2) |
申请公布日期 |
2006.05.30 |
申请号 |
US20020099352 |
申请日期 |
2002.03.13 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS |
发明人 |
JOHNSON CLAYTON H.;YORK J. LYNDAL;MCEWEN JOAN E. |
分类号 |
C12Q1/68;C07H21/04;C12N9/08;C12P19/34;G01N33/569;G01N33/573 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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