| 摘要 |
<p>The invention relates to a process for preparing a cephalosporine deacylated at the 7-amino group, by fermentation of cephalosporine-producing microorganisms in the presence of one part of the precursor chain, extraction of the N-substituted cephalosporine compound present in the fermentation broth or fluid or in an organic solvent, re-extraction of the N-substituted cephalosporine compound in water, treatment of the aqueous phase with a dicarboxylated acylase and isolation of the cephalosporine compound crystals from the conversion solution so obtained by crystallization.</p> |
