EPOXYSUCCINIC ACID DERIVATIVES

摘要

An epoxysuccinic acid derivative having the following formula: (see formula I) [wherein R1 is hydrogen, alkyl, aryl, or aralkyl; each of R2 and R3 independently is aryl, aralkyl or alkyl; X is -O- or -NR4-; and R4 is hydrogen, alkyl, or aralkyl] is useful for prevention and treatment of bone diseases such as osteoporosis, malignant hypercalcemia and Paget's syndrome, and further useful for treatment of osteoarthritis and rheumatoid arthritis which are accompanied by abnormal enhancement of cathepsin L activity, and furthermore useful as a medicine for treating diseases in which cathepsin B and L participate, such as muscular dystrophy and muscular atrophy.