Triazaspiro[5.5]undecane derivatives and drugs containing the same as the active ingredient

摘要

Triazaspiro[5.5]undecane derivatives of the formula (I), quaternary ammonium salts thereof, N-oxides thereof, non-toxic salts thereof, or pharmaceutical compositions comprising them, as active ingredients (wherein R¹ is formula (II) or formula (III); R² is alkyl or alkynyl etc.; R³, R⁴ is H, (substituted) alkyl etc., or R³ and R⁴ together to form formula (IV); R⁵ is H or alkyl). Therefore the compounds of the formula (I) regulate the effect of chemokine/chemokine receptor, they are used for prevention and treatment of various inflammatory diseases, asthma, atopic dermatitis, urticaria, allergic diseases, nephritis, nephropathy, hepatitis, arthritis or rheumatoid arthritis etc.