РИМЕНЕНИЕ ПРОИЗВОДНЫХ ИЗОХИНОЛИНА ДЛЯ ЛЕЧЕНИЯ РАКА И ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С КИНАЗОЙ МАР

摘要

This invention relates to the treatment of a disease that is characterized by an aberrant MAP kinase signaling pathway by administering a compound of the formula (I) wherein the variable substituents are defined herein, to a patient in need of such treatment. The inventive method is especially useful for the treatment of cancers that have a mutated RAF kinase, especially melanoma.