ANTIBODIES DIRECTED TO TEN-M PROTEINS AND USES THEREOF

摘要

The present invention is related to fully human antibodies directed to Ten-M4 and uses of such antibodies. Provided are human monoclonal antibodies directed to Ten-M4. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided. Some of the antibodies can inhibit the metastasis of tumors. Some of the antibodies can be used for delivering an agent, such as a toxin, to a particular target.