Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors

摘要

A compound of the formula (1) is described, as well as its pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs. A is an aryl group; Q1 is a covalent bond or an aryl leader group; J is a sulfonamide linkage of the disclosed formula; R1 is a sulfonamido substituent; and Q2 is an acid leader group. When A is a C5-20 aryl group, the aryl leader group, if present, is: a C1-7alkylene group; the sulfonamido substituent, R1, is: hydrogen, C1-7alkyl, C3-20heterocyclyl, or C5-20aryl; the acid leader group, Q is: C4-7alkylene having a backbone length of from 4 to 7 carbon atoms. The use of the compound is described to be for the manufacture of a medicament for use in the treatment of a proliferative condition.