DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE (RISC)

摘要

The invention provides a human RISC which is associated with the cardiovascular diseases, infections, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, muscle skeleton diseases, respiratory diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, muscle skeleton diseases, respiratory diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of RISC as well as pharmaceutical compositions comprising such compounds.